期刊论文

Non-enzymatic glycation of myoglobin and its biological consequences

中文

生命的化学

1000-1336

2013

33

6

627-632

10.13488/j.smhx.2013.06.002

本校为第一机构

蛋白质的非酶糖化（non-enzymatic glycation）在糖尿病及其并发症的发生发展中起着重要作用。糖化血红蛋白（hemoglobin A1c,HbA1C）已作为糖尿病患者血糖控制的"金标准"。相对而言,同为血红素蛋白的肌红蛋白（myoglobin,Mb）,其非酶糖化的研究相对较少。研究发现:非酶糖化能改变Mb的空间构象,且对Mb血红素活性中心产生一定的影响,从而导致Mb各种生物学功能发生一定程度的改变。本文综述非酶糖化对Mb结构与功能的影响的研究现状,旨在阐明Mb非酶糖化后的结构-性质-功能之间的关系及其生物学意义,为糖尿病及其并发症的发病机制研究提供新的线索。

Non-enzymatic glycation of protein plays a diabetes and its complications. Hemoglobin Alc （HbAlc） crucial role in the occurrence and development of has been used as a gold standard of controlling the blood sugar level for diabetics. Comparatively, few studies have been reported on the non-enzymatic glycation of myoglobin （Mb） and its biological consequences. Studies have showed that non-enzymatic glycation will alter the overall structure of Mb as well as its heme active center. Moreover, the structural changes lead to multiple functional c...