期刊论文

Zeng, Tiebing;Ling, Hui

英文

Clinica Chimica Acta

0009-8981

2019

489

10-20

10.1016/j.cca.2018.11.028

This work was supported by the construct program of the key discipline in Hunan Province , China (Basic Medicine Sciences in University of South China ), Center for Gastric Cancer Research of Hunan Province ( University of South China ), Key Laboratory of Tumour Cellular & Molecular Pathology ( University of South China ), College of Hunan Province. This work was also supported by the National Natural Science Foundation of China (Nos. 30600285 , 81071966 ), the Key Project of Hunan Province Science and Technology Plan (No. 2012SK2012 ), the Scientific Research Fund of Hunan Provincial Education Department (No. 12K093 ), the Science Research Project of Hunan Provincial Department of Education (Grant No: 16c1398 ), and the Science Research and Innovation Project of Hunan Provincial Postgraduate.

本校为第一且通讯机构

Autophagy, which is tightly regulated by a series of autophagy-related genes (ATGs), is a vital intracellular homeostatic process through which defective proteins and organelles are degraded and recycled under starvation, hypoxia or other specific cellular stress conditions. For both normal cells and tumour cells, autophagy not only sustains cell survival but can also promote cell death. Autophagy-related signalling pathways include mTOR-dependent pathways, such as the AMPK/mTOR and PI3K/Akt/mTOR pathways, and non-mTOR dependent pathways, such as the P53 pathway. Additionally, autophagy plays ...