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Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice

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成果类型:
期刊论文
作者:
Tian, Shao-Wen*;Yu, Xu-Dong*;Cen, Lian;Xiao, Zhi-Yong
通讯作者:
Tian, Shao-Wen;Yu, Xu-Dong
作者机构:
[Cen, Lian; Yu, Xu-Dong; Tian, Shao-Wen; Yu, XD] Univ South China, Hengyang Med Coll, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.
[Xiao, Zhi-Yong] Univ South China, Dept Anesthesiol, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Tian, SW; Yu, XD] U
Univ South China, Hengyang Med Coll, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
GLT1;Glutamate;Astrocyte;Learning;Memory
期刊:
Physiology & Behavior
ISSN:
0031-9384
年:
2019
卷:
199
页码:
28-32
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81771170]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ3465, 2018JJ2359]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Glutamate transporter GLT1 mediates glutamate uptake, and maintains glutamate homeostasis in the synaptic cleft. Previous studies suggest that blockade of glutamate uptake affects synaptic transmission and plasticity. However, the effect of GLT1 blockade on learning and memory still receives little attention. In the present study, we examined the effect of unilateral intracerebroventricular injection of dihydrokainic acid (DHK), a GLT-1 inhibitor, on novel object recognition (NOR) memory performance. The NOR task involved three sessions including habituation, sampling and test. In experiment 1...

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