National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21177052]; Science and Technology Program of Hunan Province in China [2010SK3039]; Construct Program of the Key Discipline (Public Health and Preventive Medicine) in Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
公共卫生学院
摘要:
A resonance light scattering (RLS) method has been developed using a uranyl (UO22+) specific DNAzyme and gold nanoparticles (AuNPs). In this strategy, the cleavage of the substrate strand (SDNA) of DNAzyme results in releasing a shorter duplex in the presence of UO22+, leading to the aggregation of AuNPs and the increase of RLS intensity. The response signals linearly correlated with the concentration of UO22+ over the range of 1.36 ×10-8-1.50 ×10-7 mol L-1. The limit of detection (LOD) is 4.09 ×10-9 mol L-1. The method has excellent selectivity and higher sensitivity. It cou...