miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bc1-2

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Lipeng;Yu, Xiaohua;Guo, Xiaofang;Tian, Zhi;Su, Min;...

通讯作者：

Wang, Xiaochun

作者机构：

[Zhou, Feng; Liu, Lipeng; Tian, Zhi; Su, Min; Huang, Chunxia; Liu, Meiling; Guo, Xiaofang; Long, Yu] Changsha Med Univ, Dept Biochem & Mol Biol, Changsha 410219, Hunan, Peoples R China.

[Wang, Xiaochun] Cent S Univ, Dept Med Lab Examinat, Changsha 410013, Hunan, Peoples R China.

[Yu, Xiaohua] Nanhua Univ, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Wu, Xinhua] Cent S Univ, Xiangya Hosp, Dept Obstet & Gynecol, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Wang, Xiaochun] C

Cent S Univ, Dept Med Lab Examinat, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

Apoptosis;Bcl-2;HeLa;MiR-143;Proliferation

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2012

卷：

期：

页码：

753-760

DOI：

10.3892/mmr.2011.696

基金类别：

Department of Obstetrics and Gynecology, Xiangya Hospital; The National Natural Science Foundation of Hunan Province [7JJ3058]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

microRNAs (miRNAs) are small non-coding RNA molecules of 21-24 nt that regulate the expression of other genes by transcriptional inhibition or translational repression. Multiple lines of evidence suggest that miRNAs play important roles in tumor development and progression. We identified 24 mi RNAs markedly and aberrantly expressed in human cervical cancer. The most significantly deregulated was miR-143 as determined by miRNA microarray analysis. miR-143 was introduced into He La cells and it was found that the overexpression of miR-143 significantly inhibited He La cell proliferation and prom...

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miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bc1-2

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