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miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma.

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WOS被引频次:91
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成果类型:
期刊论文
作者:
Deng, Min;Tang, Hailin;Zhou, Yanhong;Zhou, Ming;Xiong, Wei;Zheng, Ying;Ye, Qiurong;Zeng, Xi;Liao, Qianjin;Guo, Xiaofang;Li, Xiaoling;Ma, Jian;Li, Guiyuan
通讯作者:
Ma, J
作者机构:
[Li, Guiyuan; Zeng, Xi; Deng, Min; Tang, Hailin; Liao, Qianjin; Zhou, Yanhong; Xiong, Wei; Guo, Xiaofang; Zheng, Ying; Zhou, Ming; Ma, Jian; Li, Xiaoling; Ye, Qiurong] Cent S Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China.
[Zeng, Xi; Deng, Min; Tang, Hailin; Liao, Qianjin] Univ S China, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Ma, J] Cent S Univ, Canc Res Inst, 110 Xiang Ya Rd, Changsha 410078, Hunan, Peoples R China.
语种:
英文
关键词:
microRNA-216b;KRAS;Nasopharyngeal carcinoma
期刊:
Journal of cell science
ISSN:
0021-9533
年:
2011
卷:
124
期:
17
页码:
2997-3005
文献类别:
WOS:Article
所属学科:
ESI学科类别:分子生物学&遗传学;WOS学科类别:Cell Biology
入藏号:
PMID:21878506
基金类别:
China National Key Scientific Technology Programs [2006CB910502]; National 863 High Technology Program [2007AA02Z170]; National Nature Scientific Foundation of China [30871282]; Hunan Province Nature Scientific Foundation [08JJ3051]; 111 Project [111-2-12]
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
MicroRNAs (miRNAs) are small noncoding RNAs that are involved in various diseases, including cancer. In the present study, we found that miR-216b was downregulated in nasopharyngeal carcinoma (NPC) cell lines and specimens. Decreased expression of miR-216b was directly related to advanced clinical stage and lymph node metastasis. miR-216b levels correlated inversely with levels of KRAS protein during nasopharyngeal tumorigenesis. Furthermore, we demonstrated that miR-216b can bind to the 3' untranslated region (UTR) of KRAS and inhibit expression of the KRAS protein. Both in vitro and in vivo assays revealed that miR-216b attenuated NPC cell proliferation, invasion and tumor growth in nude mice. miR-216b exerts its tumor suppressor function through inhibition of the KRAS-related AKT and ERK pathways. Our findings provide, for the first time, significant clues regarding the role of miR-216b as a tumor suppressor by targeting KRAS in NPC.
参考文献:
ALMOGUERA C, 1988, CELL, V53, P549, DOI 10.1016/0092-8674(88)90571-5
Vasilatou D, 2010, EUR J HAEMATOL, V84, P1, DOI 10.1111/j.1600-0609.2009.01348.x
Segura MF, 2009, P NATL ACAD SCI USA, V106, P1814, DOI 10.1073/pnas.0808263106
Deng LW, 1998, GENE CHROMOSOME CANC, V23, P21, DOI 10.1002/(SICI)1098-2264(199809)23:1<21::AID-GCC4>3.0.CO
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