期刊论文

Wu, Yimou

英文

Infection and Immunity

0019-9567

2013

81

8

2962-2971

10.1128/IAI.00161-13

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC); National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537] Funding Source: NIH RePORTER

本校为第一且通讯机构

The p35 molecule is unique to interleukin-12 (IL-12), while p40 is shared by both IL-12 and IL-23. IL-12 promotes Th1 T cell responses, while IL-23 promotes Th17 T cell responses. The roles of IL-12p35-and IL-12p40-mediated responses in chlamydial infection were compared in mice following an intravaginal infection with Chlamydia muridarum. Mice deficient in either IL-12p35 or p40 both developed similar but prolonged infection time courses, confirming the roles of IL-12-mediated immune responses in clearing primary infection. However, all mice, ...