Interleukin-18 and interleukin-12 together downregulate ATP-binding cassette transporter A1 expression through the interleukin-18R/nuclear factor-κB signaling pathway in THP-1 macrophage-derived foam cells

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成果类型：

期刊论文

作者：

Yu, Xiao-Hua;Jiang, Hai-Lu;Chen, Wu-Jun;Yin, Kai;Zhao, Guo-Jun;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Zhao, Guo-Jun; Lv, Yun-Cheng; Jiang, Zhi-Sheng; Tang, Chao-Ke; Yu, Xiao-Hua; Yin, Kai; Ouyang, Xin-Ping; Chen, Wu-Jun; Mo, Zhong-Cheng] Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

[Yu, Xiao-Hua] Univ S China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[Jiang, Hai-Lu] Shenzhen Second Peoples Hosp, Dept Phys Examinat, Shenzhen, Guangdong, Peoples R China.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ATP-binding cassette transporter A1;Interleukin-12;Interleukin-18;Liver X receptor alpha;Nuclear factor-kappa B

期刊：

Circulation Journal

ISSN：

1346-9843

年：

2012

卷：

期：

页码：

1780-1791

DOI：

10.1253/circj.CJ-11-1338

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070220, 81170278]; Aid Program for Science and Techology Innovative Research Team in Higher Educational Institutions of Human Province, China [2008-244]

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

护理学院

摘要：

Background: Interleukin (IL)-18 and IL-12 synergize for the production of interferon (IFN)-γ, which can downregulate ATP-binding cassette transporter A1 (ABCA1) expression. The aim of the present study was to investigate the effect of IL-18 and/or IL-12 on ABCA1 expression. Methods and Results: IL-18 combined with IL-12 decreased ABCA1 expression and cellular cholesterol efflux in THP-1 macrophage-derived foam cells, whereas IL-18 or IL-12 alone had no effect. IL-12 increased IL-18 receptor (IL-18R) expression, which was suppressed by small in...

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Interleukin-18 and interleukin-12 together downregulate ATP-binding cassette transporter A1 expression through the interleukin-18R/nuclear factor-κB signaling pathway in THP-1 macrophage-derived foam cells

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