期刊论文

Lin, Ying-Wu

英文

Journal of Inorganic Biochemistry

0162-0134

2013

129

162-171

10.1016/j.jinorgbio.2013.07.023

Heme-based sensor proteins are a new class of heme-containing proteins revealed in biological systems. The function of these proteins is to sense O2, NO, or CO, and to initiate the chemistry required to adapt to changes in availability of the ligand. To date, many heme-based sensor proteins have been discovered, and the most characterized proteins are the bacterial O2 sensor FixL, the mammalian NO receptor soluble guanylate cyclase (sGC), and the bacterial CO sensor CooA, as well-reviewed by a

本校为第一且通讯机构

Heme proteins perform various biological functions ranging from electron transfer, oxygen binding and transport, catalysis, to signaling. Although adopting proper native states is very important for these functions, progresses in representative heme proteins, including cytochrome c (cyt c), cytochrome b5 (cyt b5), myoglobin (Mb), neuroglobin (Ngb), cytochrome P450 (CYP) and heme-based sensor proteins such as CO sensor CooA, showed that various native functions, or new functions evolved, are also closely associated with non-native states. The structure and function relationship of heme proteins...