期刊论文

Cao, X.

中文

卫生研究

1000-8020

2009

38

6

667-671

10.19813/j.cnki.weishengyanjiu.2009.06.009

国家自然科学基金(No.30572191) 南华大学博士启动基金(No.5-2005-XQD-001)资助

本校为第一机构

目的 探讨甲醛致胎鼠肝微核率与染色体畸变.方法 随机将妊娠小鼠(孕13天)分为5组:腹腔注射甲醛(0.00、0.20、2.00、20.00mg/kg)染毒组、环磷酰胺(30mg/kg)阳性对照组,实验至妊娠第14天即染毒后18小时脱颈椎处死孕鼠,剥离两侧子宫,每侧各取一胎鼠,断头放出外周血,取胎肝,采用胎肝微核试验和胎肝染色体畸变试验,检测胎肝血微核率和染色体畸变率.结果 2.00、20.00 mg/kg甲醛染毒组胎肝微核率及胎肝染色体畸变率与阴性对照组比较差异有显著性(P

OBJECTIVE: To study the micronucleus rate and chromosome aberration of mouse embryo liver induced by formaldehyde. METHODS: The pregnant mice (been pregnant for 13 days) were divided into 5 groups randomly: Formaldehyde was given as intraperitoneal injection (0.00, 0.20, 2.00, 20.00 mg/kg) for exposure group and Cyclophosphamide (30 mg/kg) for positive control group. When the 14th days (i.e After exposed in formaldehyde 18 hours), escapes the cervical vertebra cervical killed off pregnant mouse, peels on both sides of the uterus, takes an embryo respectively each side, beheads and emits the ci...