期刊论文

Li ZhongYu

英文

中国科学:生命科学(英文版)

1674-7305

2013

56

5

460-466

10.1007/s11427-013-4470-8

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30970165, 81102230]; Team Project for the Technology Innovation of Higher Education of Hunan Province, China; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537, R01AI064537] Funding Source: NIH RePORTER

本校为第一且通讯机构

Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy. Pathogenesis of infection has been mostly attributed to excessive cytokine production. However, precise mechanisms on how C. trachomatis triggers this production, and which protein(s) stimulate inflammatory cytokines remains unknown. In the present study, the C. trachomatis pORF5 protein induced tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-8 (IL-8) in dose- and time-dependent manners in the THP-1 human monoc...