SUMOylation of Fragile X Mental Retardation Protein:A Critical Mechanism of FMRP-Mediated Neuronal Function

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成果类型：

期刊论文

作者：

Mingzhu Tang;Liqun Lu;Feng Xie;Linxi Chen

通讯作者：

Feng Xie<&wdkj&>Linxi Chen

作者机构：

[Liqun Lu; Mingzhu Tang] Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China

[Feng Xie] Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China. 764136587@qq.com

[Linxi Chen] Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China. lxchen6@126.com

通讯机构：

[Feng Xie; Linxi Chen] I

Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China<&wdkj&>Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China

语种：

英文

关键词：

Critical Mechanism;Neuronal Function;Fragile X Mental Retardation Protein (FMRP);Small Ubiquitin-like Modifier (SUMO);methyl-CpG-binding Protein 2 (MeCP2)

期刊：

神经科学通报

ISSN：

1673-7067

年：

2018

卷：

期：

页码：

1100-1102

DOI：

10.1007/s12264-018-0290-y

基金类别：

supported by the National Natural Science Foundation of China （81503074）；

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Recently,Khayachi et al.showed that fragile X mental retardation protein (FMRP) is an active substrate of the small ubiquitin-like modifier (SUMO) pathway in neurons.FMRP SUMOylation is induced by the activation of metabotropic glutamate receptors (mGlu5Rs).FMRP SUMOylation is required for dissociating FMRP from dendritic RNA granules and controlling spine density and proper maturation.Mechanically,the SUMOylation process is triggered by the activation of mGlu5Rs,thereby contributing to maintaining FMRP-mediated neuronal function.In fact,some proteins that mediate synaptic plasticity,neurotran...

摘要(中文)：

Recently, Khayachi et al.[1] showed that fragile X mental retardation protein （FMRP） is an active substrate of the small ubiquitin-like modifier （SUMO） pathway in neurons.FMRP SUMOylation is induced by the activation of metabotropic glutamate receptor...

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