Exposure to MC-LR has been shown to cause multiple organ injury, particularly liver injury, and altered energy metabolism is closely linked. As an effective and efficient way to regulate biological gene expression, N(6)-methyladenosine(m(6)A) modification plays an important role in liver injury caused by microcystin-LR(MC-LR) exposure. For the first time, we reveal the dual mechanism by which AlkB homolog 5(ALKBH5) regulates energy metabolism through an m(6)A-YTHDF3-dependent mechanism. After MC-LR exposure, low levels of ALKBH5 increased the m(6)A modification of Phosphoinositide-3-Kinase Reg...
