MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Lv, Yun-Cheng;Tang, Yan-Yan;Peng, Juan;Zhao, Guo-Jun;Yang, Jing;...

通讯作者：

Tian, Guo-Ping

作者机构：

[He, Ping-Ping; Ouyang, Xin-Ping; Peng, Juan; Zhang, Min; Liu, Dan; Zhao, Guo-Jun; Lv, Yun-Cheng; Tang, Chao-Ke; Tan, Yu-Lin; Xie, Wei; Tang, Yan-Yan; Yang, Jing; Yao, Feng] Univ South China, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

[Lv, Yun-Cheng; Xie, Wei] Univ South China, Lab Clin Anat, Hengyang 421001, Peoples R China.

[Yang, Jing] Univ South China, Affiliated Hosp 1, Clin Med Res Inst, Hengyang 421001, Hunan, Peoples R China.

[Tian, Guo-Ping] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

[Tang, Deng-Pei] Univ Saskatchewan, Dept Biochem, Saskatoon, SK S7N 0W0, Canada.

通讯机构：

[Tian, Guo-Ping] U

Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ABCA1;Atherosclerosis;Cholesterol accumulation;Macrophage;miR-19b

期刊：

Atherosclerosis

ISSN：

0021-9150

年：

2014

卷：

236

期：

页码：

215-226

DOI：

10.1016/j.atherosclerosis.2014.07.005

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81170278, 81370377, 81300224, 81100560]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [14JJ2091]; Scientific Research Fund of Hunan Provincial Education Department, ChinaHunan Provincial Education Department [12C0339]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, China [2008-244]; construct program of the key discipline in Hunan Province

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Rationale: Macrophage accumulation of cholesterol leads to foam cell formation which is a major pathological event of atherosclerosis. Recent studies have shown that microRNA (miR)-19b might play an important role in cholesterol metabolism and atherosclerotic diseases. Here, we have identified miR-19b binding to the 3'UTR of ATP-binding cassette transporter A1 (ABCA1) transporters, and further determined the potential roles of this novel interaction in atherogenesis. Objective: To investigate the molecular mechanisms involved in a miR-19b promotion of macrophage cholesterol accumulation and th...

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MicroRNA-19b promotes macrophage cholesterol accumulation and aortic atherosclerosis by targeting ATP-binding cassette transporter A1

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