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Matrine inhibits vascular smooth muscle cell proliferation by modulating the expression of cell cycle regulatory genes

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成果类型:
期刊论文
作者:
Zhu, Ping;Chen, Ji-mei;Chen, Shu-zhen;Zhang, Cheng;Zheng, Shao-yi;...
通讯作者:
Zhuang, Jian
作者机构:
[Chen, Ji-mei; Zhang, Cheng; Zhou, Zhi-ling; Fan, Rui-xin; Zhuang, Jian; Fan, Xiao-ping; Zhu, Ping; Zheng, Shao-yi] Guangdong Gen Hosp, Dept Cardiovasc Surg, Guangdong Cardiovasc Inst, Guangzhou 510100, Guangdong, Peoples R China.
[Chen, Ji-mei; Zhang, Cheng; Zhou, Zhi-ling; Fan, Rui-xin; Zhuang, Jian; Fan, Xiao-ping; Zhu, Ping; Zheng, Shao-yi] Guangdong Acad Med Sci, Guangzhou 510100, Guangdong, Peoples R China.
[Chen, Ji; Chen, Shu-zhen; Chen, Yan-fang] Wright State Univ, Dept Pharmacol & Toxicol, Boonshoft Sch Med, Dayton, OH 45435 USA.
[Long, Guang] Nanhua Univ, Sch Med, Hengyang 421001, Peoples R China.
通讯机构:
[Zhuang, Jian] G
Guangdong Gen Hosp, Dept Cardiovasc Surg, Guangdong Cardiovasc Inst, Guangzhou 510100, Guangdong, Peoples R China.
语种:
英文
关键词:
matrine;vascular smooth muscle cells;proliferation;cell cycle;p21;p27;cyclin D1, cyclin E;cdk 2;cdk 4
关键词(中文):
血管平滑肌细胞;调控基因表达;细胞周期调控;细胞增殖;苦参碱;细胞周期蛋白依赖性激酶;细胞周期蛋白D1;P21基因
期刊:
中国药理学报
ISSN:
1671-4083
年:
2010
卷:
31
期:
10
页码:
1329-1335
基金类别:
Major International (Regional) Joint Research Project [2008DFA31140]; American Diabetes AssociationAmerican Diabetes Association [1-10-BS-25]
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Aim: To investigate the effect of matrine on proliferation of vascular smooth muscle cells (VSMCs) and elucidate the underlying mechanisms. Methods: Rat aortic VSMCs were cultured in medium supplemented with 10% fetal bovine serum and treated with various concentrations (0, 5, 10, 15, and 20 mg/L) of matrine for 72 h. VSMCs proliferation and cell cycle profiling were assessed using a methylene blue incorporation assay and flow cytometry, respectively. The underlying protein signaling mechanisms were determined using Western blot analysis of the...

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