The role of autophagy in cardiac hypertrophy

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Lanfang;Xu, Jin;He, Lu;Peng, Lijun;Zhong, Qiaoqing;...

通讯作者：

Jiang, Zhisheng;Chen, Linxi

作者机构：

[Li, Lanfang; Jiang, Zhisheng; Peng, Lijun; Zhong, Qiaoqing] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Postdoctoral Mobile Stat Basic Med, Hengyang 421001, Peoples R China.

[Li, Lanfang; Peng, Lijun] Univ South China, Hunan Childrens Hosp, Changsha 410007, Hunan, Peoples R China.

[Li, Lanfang; Peng, Lijun] Univ South China, Sch Pediat, Changsha 410007, Hunan, Peoples R China.

[Xu, Jin; He, Lu; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.

通讯机构：

[Jiang, Zhisheng; Chen, Linxi] U

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Postdoctoral Mobile Stat Basic Med, Hengyang 421001, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

autophagy;cardiac hypertrophy;cardiac function;cell signaling;autophagic flux

关键词(中文)：

心肌肥大;自噬;心肌肥厚;心肌细胞;蛋白质合成;哺乳动物;危险因素;心力衰竭

期刊：

生物化学与生物物理学报

ISSN：

1672-9145

年：

2016

卷：

期：

页码：

491-500

DOI：

10.1093/abbs/gmw025

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470434, 81270420, 81470435, 30971169]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [14JJ3102]; Hunan Provincial Science and Technology Project [2015RS4040]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2014M560647, 2015T80875]; Administration of Traditional Chinese Medicine of Hunan Province [201578]; Health and Family Planning Commission of Hunan Province [B2015-48]; Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province [2008-244]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Autophagy is conserved in nature from lower eukaryotes to mammals and is an important self-cannibalizing, degradative process that contributes to the elimination of superfluous materials. Cardiac hypertrophy is primarily characterized by excess protein synthesis, increased cardiomyocyte size, and thickened ventricular walls and is a major risk factor that promotes arrhythmia and heart failure. In recent years, cardiomyocyte autophagy has been considered to play a role in controlling the hypertrophic response. However, the beneficial or aggravating role of cardiomyocyte autophagy in cardiac hyp...

摘要(中文)：

Autophagy 从更低的优核质在自然被保存到哺乳动物并且是一重要自我吃， degradative processthat 贡献过剩材料的消除。心脏的肥大被过量 proteinsynthesis，增加的 cardiomyocyte 尺寸，和变厚的室的墙首先描绘并且是支持 arrhythmiaand 心失败的一个主要风险因素。在最近的年里， cardiomyocyte autophagy 被认为在控制 hypertrophicresponse 起一个作用。然而，在心脏的肥大的 cardiomyocyte autophagy 的有益或加重的角色仍然是在心脏的肥大的 cardiomyocyte autophagy 的准确机制进一步要求的 controversial.The 学习。在这评论，我们在心脏的肥大与 autophagy 联系的 summarizethe 争吵并...

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The role of autophagy in cardiac hypertrophy

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