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ERK1/2 mediates lung adenocarcinoma cell proliferation and autophagy induced by apelin-13

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成果类型:
期刊论文
作者:
Yang, Li;Su, Tao;Lv, Deguan;Xie, Feng;Liu, Wei;...
通讯作者:
Li, Lanfang
作者机构:
[Xie, Feng; Su, Tao; Liu, Wei; Li, Lanfang; Lv, Deguan; Qin, Xuping; Yang, Li; Cao, Jiangang; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
[Yang, Li] Yangtze Univ, Affiliated Hosp 1, Peoples Hosp Jingzhou 1, Dept Pharm, Jinzhou 434000, Peoples R China.
[Sheikh, Irshad Ali] Natl Inst Cholera & Enter Dis, Mol Pathophysiol Div, Kolkata 700010, India.
通讯机构:
[Li, Lanfang] U
Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
apelin;APJ;lung adenocarcinoma;ERK1/2;proliferation;autophagy
关键词(中文):
诱导组织;细胞增殖;自噬作用;肺腺癌;介导;细胞周期蛋白D1;A549细胞;酶联免疫吸附法
期刊:
生物化学与生物物理学报
ISSN:
1672-9145
年:
2014
卷:
46
期:
2
页码:
100-111
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270420, 30901577]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education MinistryScientific Research Foundation for the Returned Overseas Chinese Scholars [20091590]; Hengyang Joint Funds of Hunan Provincial Natural Science Foundation of China [12JJ8013]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [14JJ3102]; Open Fund Project of Key Laboratory in Hunan Universities [10K051]; Construct Program of the Key Discipline in Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
The aim of this study was to investigate the role of apelin in the cell proliferation and autophagy of lung adenocarcinoma. The over-expression of APJ in lung adenocarcinoma was detected by immunohistochemistry, while plasma apelin level in lung cancer patients was measured by enzyme-linked immunosorbent assay. Our findings revealed that apelin-13 significantly increased the phosphorylation of ERK1/2, the expression of cyclin D1, microtubule-associated protein 1 light chain 3A/B (LC3A/B), and beclin1, and confirmed that apelin-13 promoted A549 cell proliferation and induced A549 cell autophagy...
摘要(中文):
这研究的目的是在房间增长和肺腺癌的 autophagy 调查 apelin 的角色。在肺腺癌的 APJ 的在表示上被 immunohistochemistry 检测,当在肺癌症病人的血浆 apelin 水平被连接酶的 immunosorbent 试金测量时。我们的调查结果表明 apelin-13 显著地增加了 ERK1/2 的 phosphorylation, cyclin D1 的表示,联系微导管的蛋白质 1 轻链 3A/B (LC3A/B ) ,和 beclin1,并且证实 apelin-13 支持了 A549 房间增长并且经由 ERK1/2 发信号导致了 A549 房间 autophagy。而且,人的肺腺癌房间线 A549 的表面和光滑、光滑的 apelin-13 原因房间表面上有毛孔是在原子力量下面观察了显微镜学。这些结果建议 ERK1/...

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