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A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway

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成果类型:
期刊论文
作者:
Xie, Feng;Liu, Wei;Feng, Fen;Li, Xin;Yang, Li;...
通讯作者:
Li, Lanfang
作者机构:
[Xie, Feng; Liu, Wei; Li, Lanfang; Lv, Deguan; Qin, Xuping; Yang, Li; Feng, Fen; Li, Xin; Chen, Linxi] Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
[Liu, Wei] Cent S Univ, Dept Pharm, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.
通讯机构:
[Li, Lanfang] U
Univ South China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
apelin;static pressure;APJ;hypertrophy;PI3K;autophagy
关键词(中文):
心肌细胞肥大;静态压力;压力敏感;自噬;受体;大鼠模型;心肌肥厚
期刊:
生物化学与生物物理学报
ISSN:
1672-9145
年:
2014
卷:
46
期:
8
页码:
699-708
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270420, 30901577]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education MinistryScientific Research Foundation for the Returned Overseas Chinese Scholars [20091590]; Heng Yang Joint Funds of Hunan Provincial Natural Science Foundation of China [12JJ8013]; Open Fund Project of Key Laboratory in Hunan Universities [10K051]; Construct Program of the Key Discipline in Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
This study is designed to investigate whether APJ receptor acts as a sensor in static pressure-induced cardiomyocyte hypertrophy and to investigate the mechanism of PI3K-autophagy pathway. The left ventricular hypertrophy rat model was established by coarctation of abdominal aorta. H9c2 rat cardiomyocytes were cultured in the presence of static pressure which was given by a custom-made pressure incubator. The results revealed that the expression of apelin/APJ system, PI3K, Akt and their phosphorylation were significantly increased in the operation group. Static pressure up-regulated the APJ ex...
摘要(中文):
这研究被设计调查 APJ 受体是否在静态的导致压力的 cardiomyocyte hypertrophyand 充当一个传感器调查 PI3K-autophagy 小径的机制。左室的肥大老鼠模型是腹的主动脉的确定的 bycoarctation。H9c2 老鼠 cardiomyocytes 面对被给 bya 的静态的压力是有教养的定做的压力孵卵器。结果表明 apelin/APJ 系统, PI3K, Akt 和他们的 phosphorylationwere 的表达式显著地在操作组增加了。静态的压力起来调整在 cardiomyocytes 的 APJ 表示, PI3K phosphorylation, Akt phosphorylation, LC3-II/I 和 beclin-1 表示。APJ shRNA pGPU6/Neo-rat-399, PI3K 禁止者 LY294002, Akt 禁止者 1701-1 分别地...

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