期刊论文

Chen, Linxi

英文

生物化学与生物物理学报

1672-9145

2013

45

7

527-533

10.1093/abbs/gmt040

This work was supported by grants from the National Natural Science Foundation of China （grant numbers： 81270420, 30901577）, the Hengyang Joint Funds of Hunan Provincial Natural Science Foundation of China （12JJS013）, the Open Fund Project of Key Laboratory in Hunan Universities （10K051）, and the Construct Program of the Key Discipline in Hunan Province.

本校为第一且通讯机构

Apelin is a bioactive peptide discovered recently that has been proved to be an endogenous ligand of the APJ receptor. Apelin and APJ are widely distributed in the central nervous system and peripheral tissues. Researches have confirmed that apelin/APJ involved in a wide range of physiological and pathological functions in the cardiovascular system. Investigations indicated that apelin is a novel critical factor in the development of atherosclerosis (AS). In this review, we discuss the roles of apelin in the vascular smooth muscle cell proliferation, monocytes-endothelial cell adhesion, and an...

Apelin 是最近发现的 bioactive 肽那被证明了是 APJ 受体的内长的 ligand。Apelin 和 APJ 广泛地在中央神经系统和外部纸巾被散布。研究证实了在心血管的系统涉及大量生理、病理学的功能的那 apelin/APJ。调查显示 apelin 是在动脉粥样硬化的发展的一个新奇关键因素(作为) 。在这评论，我们在潜在地揭示新细胞的机制的脉管的光滑的肌肉房间增长， monocytes-endothelial 房间粘附，和 angiogenesis 讨论 apelin 的角色作为。就这些角色而言， apelin 和 APJ 可以是新奇治疗学的目标作为。