NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

She, Meihua;Deng, Xiaojian;Guo, Zhenyu;Laudon, Moshe;Hu, Zhuowei;...

通讯作者：

Yin, Weidong

作者机构：

[Deng, Xiaojian; Yin, Weidong; Guo, Zhenyu; She, Meihua] Univ S China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Peoples R China.

[Shen, Qingyun; Hu, Xiaobo; Su, Zehong; Yin, Weidong; She, Meihua; Luo, Yi] Univ S China, Sch Life Sci & Technol, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.

[Laudon, Moshe] Neurim Pharmaceut Ltd, Drug Discovery, Tel Aviv, Israel.

[Hu, Zhuowei] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.

[Hu, Zhuowei] Peking Union Med Coll, Beijing 100021, Peoples R China.

通讯机构：

[Yin, Weidong] U

Univ S China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

NEU-P11;Melatonin;Agonist;Body weight;Insulin sensitivity;High-fat/high-sucrose-fed

期刊：

Pharmacological Research

ISSN：

1043-6618

年：

2009

卷：

期：

页码：

248-253

DOI：

10.1016/j.phrs.2009.01.005

基金类别：

National Major Basic Research Program of China [(973) (2006CB503808)]; National Natural Sciences Foundation of China [30370675, 30470720]

机构署名：

本校为第一且通讯机构

院系归属：

化学化工学院

医学院

药学与生物科学学院

摘要：

Evidences indicate that a complex relationship exists among sleep disorders, obesity and insulin resistance. NEU-P11 is a novel melatonin agonist used in treatment of psychophysiological insomnia, and in animal studies NEU-P11 showed sleep-promoting effect. In this study, we applied NEU-P11 on obese rats to assess its potential melatoninergic effects in vivo. Obese models were established using high-fat/high-sucrose-fed for 5 months. NEU-P11 (10 mg/kg)/melatonin (4 mg/kg)/vehicle were administered by a daily intraperitoneal injection respectively for 8 weeks. Our results showed that NEU-P11 or...

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NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats

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