Analysis of the raw serum peptidomic pattern in glioma patients

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成果类型：

期刊论文

作者：

Li, Zheng;Lu, Hongmei;Yang, Jing;Zeng, Xi;Zhao, Lian;...

通讯作者：

Wang, Yanjin

作者机构：

[Li, Zheng; Zhou, Ming; Xiang, Juanjuan; Wu, Minghua; Peng, Shuping; Yang, Jing; Li, Guiyuan] Cent S Univ, Key Lab Carcinogenesis, Canc Res Inst, Minist Hlth, Changsha 410078, Hunan, Peoples R China.

[Lu, Hongmei; Li, Hongdong] Cent S Univ, Coll Chem & Chem Engn, Res Ctr Modernizat Chinese Med, Changsha 410078, Hunan, Peoples R China.

[Liao, Qianjing; Zeng, Xi] Univ South China, Canc Res Inst, Hengyang 421001, Peoples R China.

[Zhao, Lian] Cent S Univ, Dept Gastroenterol, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China.

[Wang, Yanjin] Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Wang, Yanjin] C

Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

CARS;Glioma;HCCA;MALDI-TOF MS;MB-WCX;MS;PLS-LDA;Pattern recognition;Peptide;SELDI;Variable selection;competitive adaptive reweighted sampling;mass spectrometry;matrix assisted laser desorption/ionization time-of-flight mass spectrometry;partial least-squares-linear discriminate analysis;surface-enhanced laser desorption/ionization;weak cation exchange chromatography magnetic bead;alpha-cyano-4-hydroxycinnamic acid

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2013

卷：

425

页码：

221-226

DOI：

10.1016/j.cca.2013.08.002

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81000882, 21175157]; National Training and Research Base for Talents of Principles of Carcinogenesis Foundation (111 project) [111-2-12]; Ph.D. Programs Foundation of Ministry of Education of ChinaMinistry of Education, China [20100162120080]; Excellent Ph.D. Foundation of Hunan Province of China [741000002]; Hunan Province Natural Sciences Foundation of ChinaNatural Science Foundation of Hunan Province [10JJ7003]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Background: Glioma is a common and lethal type of brain tumor. Serum peptides reflected the pathological changes of the body. Here we studied the serum peptide profiles to distinguish glioma disease and measure glioma staging. Methods: Serum peptides were captured by WCX magnetic beads and were analyzed by MALDI-TOF mass spectrometer. Sera from 53 glioma patients and 69 age-matched healthy controls were analyzed. Clinpro Tools software was used to obtain a common peak m/z list from all measured samples. An optimal subset of peptides was selected to establish a predictive classification model w...

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Analysis of the raw serum peptidomic pattern in glioma patients

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