Knowing more life process and disease types associated with miR-155-5 p,which could provide a theoretical basis for the further function study of hsa-miR-155-5 p. Bioinformatics analysis of miR-155-5 p found that the mature sequence of miR-155-5 p was highly conservative property among various species. GO analysis showed that the molecular functions of the target genes were significantly invovled in heterocyclic compound binding,nucleic acid binding,and so on;These genes were significantly associated with cellular macromolecule metabolic process,biological regulation,organic substance metabolic and other biological processes. KEGG analysis found that the target genes were mainly located in cancer pathway,MAPK signaling pathway and Fox O signaling pathway. Analysis results showed that miR-155-5 p played an important role in human living activities and disease development process through regulating target genes. It was worth to further study miR-155-5 p as a biomarker especially in the early diagnosis and prognosis of cancer.