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Impacts of uranyl ion on the structure and function of cytochrome b 5 His39Ser mutant

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成果类型:
期刊论文、会议论文
作者:
Wan, Dun;Liao, Li-fu;Lin, Ying-Wu*
通讯作者:
Lin, Ying-Wu
作者机构:
[Liao, Li-fu; Wan, Dun; Lin, Ying-Wu] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
通讯机构:
[Lin, Ying-Wu] U
Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Uranium;Heme proteins;Metal-binding site;modeling;Toxicity
期刊:
Advanced Materials Research
ISSN:
1022-6680
年:
2012
卷:
455-456
页码:
1204-1209
会议名称:
2011 International Conference on Fuzzy Systems and Neural Computing(FSNC 2011)
会议论文集名称:
Advanced Materials Research
会议时间:
2011-02-2
会议地点:
中国香港
会议主办单位:
[Wan, Dun;Liao, Li-fu;Lin, Ying-Wu] Univ S China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.
会议赞助商:
Intelligent Information Technology Application Association
主编:
Thaung, KS
出版地:
KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND
出版者:
TRANS TECH PUBLICATIONS LTD
ISBN:
978-3-03785-300-9
基金类别:
National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [20877038, 10975069]
机构署名:
本校为第一且通讯机构
院系归属:
化学化工学院
摘要:
Uranium is toxic to human body with mechanisms not fully understood. The structural and functional consequences of uranyl ions (UO22+) interacting with an axial mutant of cytochrome b5, His39Ser (cyt b5 H39S), were investigated by both spectroscopic and molecular modeling methods. Although slightly disturbs protein folding, UO22+ binding to cyt b5 H39S leads to a decrease of peroxidase activity. A uranyl binding site was further proposed in the heme-binding domain at Glu37 and Glu43. The impacts of UO22+ binding to cyt b5 H39S studied herein provide valuable insight...

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