期刊论文

Liu Yunmei

英文

高等学校化学研究：英文版

1005-9040

2014

30

6

925-930

10.1007/s40242-014-4269-6

——————————— *Corresponding author. E-mail: lymhsm2013@126.com Received July 18, 2014; accepted September 4, 2014. Supported by the Construct Program of the Key Discipline in Hunan Province, China(No.[2011]76). © Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH

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Two series of 7-O-modified chrysin derivatives were prepared from 7-O-carboxymethyl chrysin(2a), 7-O-carboxypropylchrysin(2b) and short-chain alcohols by using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride(EDCI), N-hydroxybenzotriazole(HOBt) and 4-dimethylamiopryidine(DMAP) as coupling reagents. Taking cisplatin as a reference substance, their anti-proliferative activities in vitro against human gastric carcinoma MGC-803 cells were evaluated by the standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide(MTT) meth...