期刊论文

Chen, Chunying

英文

Biomaterials

0142-9612

2015

61

307-315

10.1016/j.biomaterials.2015.05.029

Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2011CB933401, 2012CB934003, 2013DFG32340, 2014DFG52500]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21477029, 21320102003, 21277037, 21277080]; Chinese Academy of SciencesChinese Academy of Sciences [XDA09040400]; National Major Scientific Instruments Development Project [2011YQ03013406]; International Science & Technology Cooperation Program of China; Beijing Natural Science FoundationBeijing Natural Science Foundation [2152037]; European Commission through the Seventh Framework Programme for Research and Technological Development (FP7-MARINA) [263215]; Major Project of the National Social Science Fund [12ZD117]; National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [11425520]

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Silver nanoparticles (AgNPs) attract considerable public attention both for their antimicrobial properties and their potential adverse effects. In the present study, endoplasmic reticulum (ER) stress was used as a sensitive and early biomarker to evaluate the toxic potential of AgNPs in three different human cell lines in vitro and in vivo in mice. In 16HBE cells, the activation of ER stress signaling pathway was observed by upregulated expression including xbp-1s, chop/. DDIT3, TRIB3, ADM2, BIP, Caspase-12, ASNS and HERP at either the mRNA and...