Dexmedetomidine Inhibits TLR4/NF-kappa B Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yao, Hui;Chi, Xinjin*;Jin, Yi;Wang, Yiheng;Huang, Pinjie;...

通讯作者：

Chi, Xinjin

作者机构：

[Huang, Pinjie; Cai, Jun; Chi, Xinjin; Wu, Shan; Yao, Hui; Wang, Yiheng] Sun Yat Sen Univ, Dept Anesthesiol, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China.

[Jin, Yi] Sun Yat Sen Univ, Dept Pathol, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China.

[Wang, Yiheng] Univ South China, Dept Anesthesiol, Affiliated Hosp 1, Hengyang 421001, Peoples R China.

[Xia, Zhengyuan] Univ Hong Kong, Dept Anesthesiol, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China.

通讯机构：

[Chi, Xinjin] S

Sun Yat Sen Univ, Dept Anesthesiol, Affiliated Hosp 3, Guangzhou 510630, Guangdong, Peoples R China.

语种：

英文

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2015

卷：

期：

页码：

16849

DOI：

10.1038/srep16849

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471892]; Natural Science Foundation of Guangdong Province, ChinaNational Natural Science Foundation of Guangdong Province [2014A030313199]; Science and Technology Project Foundation of Guangdong Province, China [2009B030801125]; Outstanding Young Teacher Training Program of Sun Yat-sen University, China [14ykpy24]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Patients who undergo orthotopic liver transplantation often sustain acute kidney injury(AKI). The toll-like receptor 4(TLR4)/Nuclear factor-кB(NF-кB) pathway plays a role in AKI. Dexmedetomidine(Dex) has been shown to attenuate AKI. The current study aimed to determine whether liver transplantation-induced AKI is associated with inflammatory response, and to assess the effects of dexmedetomidine pretreatment on kidneys in rats following orthotopic autologous liver transplantation(OALT). Seventy-seven adult male rats were randomized into 11 gr...

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Dexmedetomidine Inhibits TLR4/NF-kappa B Activation and Reduces Acute Kidney Injury after Orthotopic Autologous Liver Transplantation in Rats

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