Calcium overload, mediated by calmodulin (CaM), plays an important role in ischemia/reperfusion injury during acute ischemic brain damage. However, the regulation of CaM expression in cerebral ischemia is still not fully addressed. This study showed that the levels of plasma miR-335 were significantly down-regulated in 152 patients with acute cerebral infarction (0.60 ± 0.31) compared to 136 age-matched healthy controls (1.16 ± 0.30) (P < 0.01). Moreover, the levels negatively correlated with the National Institutes of Health Stroke Scale (NI...
