A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer\' disease - 成果

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A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

He, Pingping;Ouyang, Xinping;Zhou, Shouhong;Yin, Weidong;Tang, Chaoke;...

通讯作者：

Tian, Shaowen

作者机构：

[He, Pingping] Univ South China, Sch Nursing, Hengyang 421001, Hunan, Peoples R China.

[Tang, Chaoke; Yin, Weidong; He, Pingping; Ouyang, Xinping] Univ South China, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Shouhong; Tian, Shaowen; Ouyang, Xinping] Univ South China, Dept Physiol, Sch Med, Hengyang 421001, Hunan, Peoples R China.

[Laudon, Moshe] Neurim Pharmaceut Ltd, Tel Aviv, Israel.

[Tian, Shaowen] Univ South China, Dept Physiol, Coll Med, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tian, Shaowen] U

Univ South China, Dept Physiol, Coll Med, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Melatonin;Neu-P11;Memory;Alzheimer' disease;Rats

期刊：

Hormones and Behavior

ISSN：

0018-506X

年：

2013

卷：

期：

页码：

1-7

DOI：

10.1016/j.yhbeh.2013.04.009

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81171281]; Neurim Pharmaceuticals Research Grant; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [10JJ2009]; Science and Technology Development Project of Hengyang Municipal Science and Technology Bureau [2012KJ37]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

护理学院

摘要：

Previous studies have shown that melatonin is implicated in modulating learning and memory processing. Melatonin also exerts neuroprotective activities against A beta-induced injury in vitro and in vivo. Neu-P11 (piromelatine, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-4-oxo-4H-pyran-2-carboxamide) is a novel melatonin (MT1/MT2) receptor agonist and a serotonin 5-HT1A/1D receptor agonist recently developed for the treatment of insomnia. In the present study we firstly investigated whether Neu-P11 and melatonin enhance memory performance in the novel object recognition (NOR) task in rats, and then as...

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A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease

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