期刊论文

Xu, Shun-qing

英文

ENVIRONMENTAL TOXICOLOGY

1520-4081

2015

30

9

1082-1090

10.1002/tox.21981

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81030051, 81273026]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [12JJ3098]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2010MS091]; Construct Program of the Key Discipline (Pubilc Health and Preventive Medicine) in Hunan Province; Science and Technology Project of Hunan Province [2012RS4010]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2011M501276]

本校为第一机构

Perfluorooctanyl sulfonate (PFOS), a cardiac toxicity compound, has been widely detected in the environment and in organisms. However, the toxic mechanism is not clear. Our previous study indicated that prenatal PFOS exposure led to swollen mitochondrial with vacuolar structure and loss of cristae in offsping's heart. The purpose of this study was to investigate the effect of PFOS on the apoptosis in developing heart and mitochondria-mediated apoptosis pathway. Pregnant Sprague-Dawley (SD) rats were exposed to PFOS at doses of 0.1, 0.6, and 2.0...