期刊论文

中文

中国动脉硬化杂志

1007-3949

2009

17

1

4-8

国家自然科学基金资助项目（30700325）； 动脉硬化学湖南省高校科技创新团队经费资助；

本校为第一机构

目的 研究沙利度胺对的动脉粥样硬化病变形成的押制作用.方法 新西兰兔分为3组,每组13只.正常饮食组给予普通饮食;高脂组给予2%的高胆固醇饮食;高脂加药组给予2%的高胆固醇饮食+20 mg/kg沙利度胺,2个月后宰杀动物,取整条主动脉行苏丹IV染色检测斑块面积,油红O染色和HE染色检测斑块的病变程度,油红O染色检测肝脏内脂质蓄积情况,不同时间点采血,检测总胆固醇、低密度脂蛋白、高密度脂蛋白和甘油三酯等血脂指标水平,ELISA方法 检测血液中肿瘤坏死因子α水平.结果 (1)高脂饮食喂养新西兰兔2个月后,总胆固醇、低密度脂蛋白和高密度脂蛋白等指标较正常饮食组明显升高.苏丹Ⅳ染色高脂组有36.7%±4.3%红...

Aim To Study the effect of Thalidomide inhibiting atherosclerogenesis. Methods Thirty nine New Zealand rabbits were divided into three groups equally. Normal diet group; High cholesterol diet group, including 2% cholesterol ; High cholesterol diet ＋ 20 mg/kg Thalidomide （Thd） group. After 2 months, the animals were killed. The whole aorta was stained with Sudan Ⅳ, and atherosclerotic plaque size was measured. The atherosclerotic lesion degree was checked after the plaque slice was stained with oil red O and HE. The accumulation of lipid in ...