To study the effect of CXCR4 antagonist AMD3100 on the atherosclerotic lesion, the expression of TNF-α and NF-κB and SDF-1α/CXCR4, so as to approach the specific role and possible mechanisms of SDF-1α/CXCR4 on atherosclerosis. 36 male apoE-/ - mice, 8 weeks old, randomly divided into three groups: 1 normal food group, 2 high fat group, 3 AMD3100 group. Animals from high fat group and AMD3100 group were fed with western food which including 15%fat and 0.25% cholesterol. After feeding 12 weeks, all mice were anesthetized by 0.2~0.3 ml Urethan...