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AMD3100促进动脉粥样硬化病变与上调炎性因子表达及下调SDF-1α/CXCR4轴有关

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成果类型:
期刊论文
作者:
Wang Zuo*;Su Wei;Zhou Xiao-Feng;Zhang Kai;Li Shuang;...
通讯作者:
Wang Zuo
作者机构:
[Ma Xiao-Feng; Wang Zuo; Jiang Zhi-Sheng; Zhang Kai; Li Shuang; Su Wei] Univ S China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Peoples R China.
[Zhou Xiao-Feng] Qinghai Univ, Affiliated Hosp, Dept Pathol, Xining 810001, Peoples R China.
通讯机构:
[Wang Zuo] U
Univ S China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Res, Hengyang 421001, Peoples R China.
语种:
中文
关键词:
基质细胞衍生因子1α;动脉粥样硬化;肿瘤坏死因子α;核因子-κB
关键词(英文):
CXCR4;AMD3100
期刊:
生物化学与生物物理进展
ISSN:
1000-3282
年:
2012
卷:
39
期:
2
页码:
168-174
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]; Science and Technology Innovative Research Team in Higher Educational Instituions of Hunan Province, Educational Foundation of Hunan Province [07C617]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
探索CXCR4阻断剂AMD3100促进apoE-/-小鼠动脉粥样硬化病变的分子机制.36只8周龄雄性apoE-/-小鼠随机分为三组:普食组、高脂组和AMD3100组.ELISA法测血清基质细胞衍生因子1α(SDF-1α)水平,采用氧化酶法测定apoE-/-小鼠血清中三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)含量.HE染色检测apoE-/-小鼠主动脉根部横切面动脉粥样硬化病变.免疫组织化学检测小鼠胸主动脉CXCR4表达.RT-PCR和Western blot分别检测小鼠动脉组织TNF-α、NF-κB mRNA和蛋白质表达.AMD3100组小鼠主动脉根部横截面的动脉粥样硬化病变较高脂组严重,AMD3100组小鼠胸腹主动脉炎症因子TNF-...
摘要(英文):
To study the effect of CXCR4 antagonist AMD3100 on the atherosclerotic lesion, the expression of TNF-α and NF-κB and SDF-1α/CXCR4, so as to approach the specific role and possible mechanisms of SDF-1α/CXCR4 on atherosclerosis. 36 male apoE-/ - mice, 8 weeks old, randomly divided into three groups: 1 normal food group, 2 high fat group, 3 AMD3100 group. Animals from high fat group and AMD3100 group were fed with western food which including 15%fat and 0.25% cholesterol. After feeding 12 weeks, all mice were anesthetized by 0.2~0.3 ml Urethan...

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