The atherosclerotic animal model was established, whose pathological changes and the plasma lipid level are as same as the atherosclerotic injury in human, and then the stability of atherosclerotic plaque was studied. The miniswine resemble human in the physiology, biochemistry and anatomy. So it is a very appropriate candidate animal for atherosclerosis study. The miniswine atherosclerotic model by high lipid and high cholesterol diet was successfully established, whose plaque included a necrotic lipid core, a thin fibrin cap, a lot of foam cells and inflammatory cells. Calcify and intraplaqu...
