Apolipoprotein A-I Inhibits CD40 Proinflammatory Signaling via ATP-Binding Cassette Transporter A1-Mediated Modulation of Lipid Raft in Macrophages

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成果类型：

期刊论文

作者：

Yin, Kai;Chen, Wu-Jun;Zhou, Zhi-Gang;Zhao, Guo-Jun;Lv, Yun-Chen;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Zhao, Guo-Jun; Jiang, Zhi-Sheng; Tang, Chao-Ke; Lv, Yun-Chen; Ouyang, Xin-Pin; Yu, Xiao-Hua; Yin, Kai; Chen, Wu-Jun; Zhou, Zhi-Gang] Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

[Yin, Kai] Univ S China, Coll Med, Dept Diagnost, Hengyang 421001, Hunan, Peoples R China.

[Zhou, Zhi-Gang] Univ S China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Fu, Yuchang] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.

通讯机构：

[Tang, Chao-Ke] U

Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Apolipoprotein A-I;ATP-binding cassette transporter A1;CD40;Lipid raft

期刊：

Journal of Atherosclerosis and Thrombosis

ISSN：

1340-3478

年：

2012

卷：

期：

页码：

823-836

DOI：

10.5551/jat.12823

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070220, 81170278, 81100213]; Post-doctoral Sciences Foundation of ChinaChina Postdoctoral Science Foundation [2005037157]; Heng Yang Joint Funds of The Hunan Provincial Natural Sciences Foundation of China [10JJ9019]; Hunan Provincial Natural Sciences Foundation of China [06jj5058]; Science & Technology Department Funds of Heng Yang of Hunan Province [2010kj17, 2010kj41]; Hunan Provincial Postgraduate Innovation Fund [CX2010B379]

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

AIM: Apolipoprotein A-I (apoA-I), the major component of high-density lipoprotein (HDL), has been recently found to suppress inflammation. This study was to investigate the effects and potential mechanisms of apoA-I on the CD40/CD40 ligand (CD40L) proinflammatory signaling pathway. METHODS: Human THP-1 macrophage-derived foam cells were treated with sCD40L alone or in the presence of apoA-I. Secretion of proinflammatory cytokines was performed by enzyme-linked immunosorbent assay(ELISA). The proteins and mRNA expression were examined by western-blot and real-time PCR analysis, respectly. Chole...

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Apolipoprotein A-I Inhibits CD40 Proinflammatory Signaling via ATP-Binding Cassette Transporter A1-Mediated Modulation of Lipid Raft in Macrophages

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