Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes

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成果类型：

期刊论文

作者：

Liu, Mi-Hua;Shan, Jian;Li, Jian;Zhang, Yuan;Lin, Xiao-Long*

通讯作者：

Lin, Xiao-Long

作者机构：

[Liu, Mi-Hua] Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China.

[Shan, Jian] Zhongshan Torch Dev Zone Hosp, Dept Pathol, Zhongshan 528437, Guangdong, Peoples R China.

[Li, Jian] BoAi Hosp Zhongshan, Dept Ultrason Diag, Zhongshan 528403, Guangdong, Peoples R China.

[Zhang, Yuan] Mawangdui Hosp, Dept Pathol, Changsha 410016, Hunan, Peoples R China.

[Lin, Xiao-Long] Guangzhou Med Univ, Affiliated Huizhou Hosp, Peoples Hosp Huizhou 3, Dept Pathol, 1 Xuebei St, Huizhou 516002, Guangdong, Peoples R China.

通讯机构：

[Lin, Xiao-Long] G

Guangzhou Med Univ, Affiliated Huizhou Hosp, Peoples Hosp Huizhou 3, Dept Pathol, 1 Xuebei St, Huizhou 516002, Guangdong, Peoples R China.

语种：

英文

关键词：

apoptosis;doxorubicin;forkhead box protein O1;resveratrol;sirtuin 1

期刊：

EXPERIMENTAL AND THERAPEUTIC MEDICINE

ISSN：

1792-0981

年：

2016

卷：

期：

页码：

1113-1118

DOI：

10.3892/etm.2016.3437

基金类别：

Graduate Student Research Innovation project of Hunan province [CX2013B397]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Doxorubicin (DOX) is an efficient drug used in cancer therapy; however, it can induce severe cytotoxicity, which limits its clinical application. In the present study, the effects of resveratrol (RES) on sirtuin 1 (SIRT1) activation in mediating DOX-induced cytotoxicity in H9c2 cardiac cells was investigated. H9c2 cells were exposed to 5 μM DOX for 24 h to establish a model of DOX cardiotoxicity. Apoptosis of H9c2 cardiomyocytes was assessed using the MTT assay and Hoechst nuclear staining. The results demonstrated that pretreating H9c2 cells ...

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Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes

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