The potential anticancer effect of beta-blockers and the genetic variations involved in the interindividual difference

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成果类型：

期刊论文

作者：

He, Ruo-Hui;He, Yi-Jing;Tang, Yong-Jun;Zhou, Hong-Hao;McLeod, Howard L.;...

通讯作者：

Liu, Jie

作者机构：

[Liu, Jie; He, Ruo-Hui; Zhou, Hong-Hao; Tang, Yong-Jun; He, Yi-Jing] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

[Liu, Jie; He, Ruo-Hui; Zhou, Hong-Hao; Tang, Yong-Jun; He, Yi-Jing] Cent S Univ, Hunan Key Lab Pharmacogenet, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China.

[Liu, Jie; He, Ruo-Hui; Zhou, Hong-Hao; Tang, Yong-Jun; He, Yi-Jing] Univ South China, Cooperat Innovat Ctr Mol Target New Drug Study, Hengyang 421001, Hunan, Peoples R China.

[McLeod, Howard L.] H Lee Moffitt Canc Ctr & Res Inst, Div Populat Sci, DeBartolo Family Personalized Med Inst, Tampa, FL 33612 USA.

通讯机构：

[Liu, Jie] C

Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

cancer progression;polymorphisms;tumor biology behaviors;beta-adrenergic receptors;beta-blockers

期刊：

PHARMACOGENOMICS

ISSN：

1462-2416

年：

2016

卷：

期：

页码：

59-74

DOI：

10.2217/pgs.15.152

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070902, 30600774]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [201104515, 2012M510138]; Program for New Century Excellent Talents in University of Ministry of Education of ChinaProgram for New Century Excellent Talents in University (NCET) [NCET-08-0567]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

β-ARs are extensively spread in different tissues of our body, which could be activated by neurotransmitters norepinephrine and epinephrine to mediate physiological function and abnormal states including cancer. Recently, β-AR blockers could have significant implications in cancer therapy. But the precise molecular mechanisms are far from being fully understood. Through identifying the β-AR system signal pathways relevant to cancer, we can understand the mechanisms of β-blockers used for cancer treatment. What's more, retrospective clinical...

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The potential anticancer effect of beta-blockers and the genetic variations involved in the interindividual difference

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