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Ox-Lp(a) transiently induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1–AMPK–mTOR pathway

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成果类型:
期刊论文
作者:
Li, Guo-hua;Lin, Xiao-long;Zhang, Hai;Li, Shuang;He, Xing-lan;...
通讯作者:
Wang, Zuo
作者机构:
[Lei, Jian-jun; Tang, Ya-ling; Wang, Ren; Li, Shuang; Peng, Juan; Zhang, Hai; He, Xing-lan; Zhang, Kai; Jiang, Zhi-Sheng; Zhao, Yue; Li, Guo-hua; Lin, Xiao-long; Ma, Xiao-feng; Wei, Dang-heng; Wang, Zuo] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
[Lin, Xiao-long] Guangzhou Med Univ, Peoples Hosp Huizhou 3, Affiliated Hui Zhou Hosp, Dept Pathol, Huizhou 516002, Guangdong, Peoples R China.
[Zhang, Kai; Zeng, Jun-fa] Univ South China, Hosp 2, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Wang, Zuo] U
Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Arteriosclerosis;Autophagy;Oxidised lipoprotein(a);Oxygen species
期刊:
Ateroskleroz
ISSN:
2078-256X
年:
2015
卷:
243
期:
1
页码:
223-235
基金类别:
Innovative Research Team for Science and Technology in Higher Educational Institutions of Hunan Province; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070221]; Visiting Scholar Foundation of Key Laboratory for Biorheological Science and Technology (Chongqing University) of Ministry of Education [cpu-moek3-br-2010]; construct program of the key discipline in Hunan province
机构署名:
本校为第一且通讯机构
院系归属:
医学院
药学与生物科学学院
摘要:
Oxidised lipoprotein(a) [oxLp(a)] is considered as a more potent arteriosclerotic factor than native Lp(a). However, the molecular mechanisms underlying this potency remain unclear. Reactive oxygen species (ROS) possibly act as intracellular second messengers that participate in autophagy stimulation. In this study, the effect of oxLp(a) on endothelial cell autophagy was determined. The mechanism and effect of autophagy on endothelial cells were also investigated. Results showed that oxLp(a) could induce autophagy depending on the generation of cellular ROS. Superoxide dismutase, an antioxidan...

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