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TGF-beta 1 Up-Regulates Expression of ABCA1, ABCG1 and SR-BI through Liver X Receptor a Signaling Pathway in THP-1 Macrophage-Derived Foam Cells

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成果类型:
期刊论文
作者:
Hu, Yan-Wei;Wang, Qian;Ma, Xin;Li, Xiao-Xu;Liu, Xie-Hong;...
通讯作者:
Tang, Chao-Ke
作者机构:
[Tang, Chao-Ke; Li, Xiao-Xu; Hu, Yan-Wei; Liu, Xie-Hong; Xiao, Ji] Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.
[Hu, Yan-Wei; Wang, Qian] So Med Univ, Lab Med Ctr, Nangfang Hosp, Guangzhou, Guangdong, Peoples R China.
[Ma, Xin] Univ S China, Dept Anesthesiol, Affiliated Hosp 1, Hengyang 421001, Hunan, Peoples R China.
[Liao, Duan-Fang] Univ S China, Inst Pharm & Pharmacol, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.
[Xiang, Jim] Univ Saskatchewan, Res Unit, Hlth Res Div, Saskatchewan Canc Agcy,Dept Oncol, Saskatoon, SK S7N 0W0, Canada.
通讯机构:
[Tang, Chao-Ke] U
Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
ABCA1;ABCG1;SR-BI;TGF-beta 1;LXR alpha;Atherosclerosis
期刊:
Journal of Atherosclerosis and Thrombosis
ISSN:
1340-3478
年:
2010
卷:
17
期:
5
页码:
493-502
基金类别:
National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30470720]; Post-doctor Sciences Foundation of ChinaChina Postdoctoral Science Foundation [2005037157]; Hunan Provincial Natural Sciences Foundation of China [06jj5058]
机构署名:
本校为第一且通讯机构
院系归属:
国防科学技术学院
医学院
药学与生物科学学院
摘要:
Aim: High density lipoprotein (HDL) and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporter A1 (ABCA1), ABCG1, and scavenger receptor class B type. (SR-BI). Liver X receptors (LXRs) operate as cholesterol sensors which may protect from cholesterol overload by stimulating cholesterol efflux from cells to HDL through ABCA1, ABCG1 and SR-BI. The regulation of ABCA1, ABCG1 and SR-BI expression by cytokines present within the microenvironment of the atheroma may play an important role in determining the impact of reverse cholesterol...

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