Activation of EGFR Promotes Squamous Carcinoma SCC10A Cell Migration and Invasion Via Inducing EMT-Like Phenotype Change and MMP-9-Mediated Degradation of E-Cadherin

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成果类型：

期刊论文

作者：

Zuo, Jian-Hong;Zhu, Wei;Li, Mao-Yu;Li, Xin-Hui;Yi, Hong;...

通讯作者：

Xiao, Zhi-Qiang

作者机构：

[Wan, Xun-Xun; Qu, Jia-Quan; Zhu, Wei; Yi, Hong; He, Qiu-Yan; Zuo, Jian-Hong; Li, Mao-Yu; Xiao, Zhi-Qiang; Li, Xin-Hui; Zeng, Gu-Qing; Li, Jian-Huang; Chen, Yu] Cent S Univ, Xiangya Hosp, Key Lab Canc Prote, Chinese Minist Hlth, Changsha 410008, Hunan, Peoples R China.

[Zuo, Jian-Hong] Univ S China, Dept Microbiol & Immunol, Sch Med, Hengyang 421001, Peoples R China.

[Zhu, Wei] Univ S China, Affiliated Hosp 1, Dept Oncol, Hengyang 421001, Peoples R China.

[Xiao, Zhi-Qiang] Cent S Univ, Xiangya Hosp, Key Lab Canc Prote, Chinese Minist Hlth, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Xiao, Zhi-Qiang] C

Cent S Univ, Xiangya Hosp, Key Lab Canc Prote, Chinese Minist Hlth, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

EGFR;HNSCC;INVASION;MMP-9;E-CADHERIN

期刊：

JOURNAL OF CELLULAR BIOCHEMISTRY

ISSN：

0730-2312

年：

2011

卷：

112

期：

页码：

2508-2517

DOI：

10.1002/jcb.23175

基金类别：

National Nature Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973290]; Ministry of Education of ChinaMinistry of Education, China [2002-48]; Lotus Scholars Program of Hunan Province [2007-362]; Science and Technology Committee of Hunan Province [2010FJ2009]; Higher Educational Institutions of Hunan Province

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

EGFR is a potent stimulator of invasion and metastasis in head and neck squamous cell carcinomas (HNSCC). However, the mechanism by which EGFR may stimulate tumor cell invasion and metastasis still need to be elucidated. In this study, we showed that activation of EGFR by EGF in HNSCC cell line SCC10A enhanced cell migration and invasion, and induced loss of epitheloid phenotype in parallel with downregulation of E-cadherin and upregulation of N-cadherin and vimentin, indicating that EGFR promoted SCC10A cell migration and invasion possibly by an epithelial to mesenchymal transition (EMT)-like...

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Activation of EGFR Promotes Squamous Carcinoma SCC10A Cell Migration and Invasion Via Inducing EMT-Like Phenotype Change and MMP-9-Mediated Degradation of E-Cadherin

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