Two sRNA RyhB homologs from Yersinia pestis biovar microtus expressed in vivo have differential Hfq-dependent stability

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Deng, Zhongliang;Meng, Xiangrong;Su, Shanchun;Liu, Zizhong;Ji, Xiaolan;...

通讯作者：

Yang, Ruifu

作者机构：

[Zhang, Yiquan; Zhao, Xiangna; Deng, Zhongliang; Liu, Zizhong; Han, Yanping; Ji, Xiaolan; Meng, Xiangrong; Su, Shanchun; Yang, Ruifu; Wang, Xiaoyi] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China.

[Deng, Zhongliang; Yang, Ruifu] So Med Univ, Guangzhou 510450, Guangdong, Peoples R China.

[Deng, Zhongliang] Univ S China, Sch Publ Hlth, Dept Sanit Inspect, Changsha 421001, Hunan, Peoples R China.

[Ji, Xiaolan; Meng, Xiangrong] Jiangsu Univ, Dept Biochem & Mol Biol, Zhenjiang 212013, Jiangsu, Peoples R China.

[Su, Shanchun] Sichuan Agr Univ, Microbiol Lab, Chengdu 625014, Sichuan, Peoples R China.

通讯机构：

[Yang, Ruifu] B

Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China.

语种：

英文

关键词：

Yersinia pestis;RyhB;Hfq-dependent stability

期刊：

Research in Microbiology

ISSN：

0923-2508

年：

2012

卷：

163

期：

6-7

页码：

413-418

DOI：

10.1016/j.resmic.2012.05.006

基金类别：

National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30971629, 31171248, 30930001]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Small non-coding RNAs (sRNAs) have been shown to modulate gene expression at the post-transcriptional level. RyhB, an iron-responsive sRNA, is conserved in Escherichia coli and other Enterobacteriae, indicating the downregulation of numerous genes during iron depletion. This sRNA is tightly regulated by the ferric uptake regulator (Fur) and interacts with the RNA binding protein Hfq. Hfq is generally purported to be essential for stabilizing sRNAs and promoting sRNA-mRNA duplex formation. Maintenance of iron homeostasis is an essential step in the lifecycle of Yersinia pestis. Y. pestis encode...

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Two sRNA RyhB homologs from Yersinia pestis biovar microtus expressed in vivo have differential Hfq-dependent stability

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