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Protective effect of the omega-3 polyunsaturated fatty acids on the schistosomiasis liver fibrosis in mice

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成果类型:
期刊论文
作者:
Wu, Yuan;Liang, Yu;Zhu, Yi;Gao, Yongqiang;Chen, Hu;...
通讯作者:
Xiao, Jianhua
作者机构:
[Liang, Yu; Li, Yingju; Yin, Weiguo; Zhang, Yukuai; Xiao, Jianhua; Gao, Yongqiang; Wu, Yuan; Wang, Kegeng] Univ South China, Coll Med, Inst Pathogen Biol, Hengyang 421001, Hunan, Peoples R China.
[Zhu, Yi; Wu, Yuan; Chen, Hu] Univ South China, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.
[Xiao, Jianhua] Univ South China, Coll Med, Inst Pathogen Biol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Xiao, Jianhua] U
Univ South China, Coll Med, Inst Pathogen Biol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Schistosoma japonicum;liver fibrosis;protective effect;omega-3 polyunsaturated fatty acids
期刊:
International Journal of Clinical and Experimental Medicine
ISSN:
1940-5901
年:
2015
卷:
8
期:
6
页码:
9470-9476
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81101274, 30972576]; Hunan Provincial Natural Science Foundation-Hengyang Joint Foundation of China [10JJ2010]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2011JJ3104]
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
This study aims to observe the effect of ω-3 polyunsaturated fatty acids on initiation and elimination of the schistosomiasis inflammatory response and liver fibrosis. The mice infected with the cercariae of Schistosoma japonicum (20 ± cercarie per mice) were separated randomly into several groups. After 60 days, liver tissue samples of all mice were sectioned. Hematoxylin-eosin (HE) staining, Masson staining, the enzyme-linked immunosorbent assay (ELISA), and flow cytometry (FCM) were performed. Through HE and Masson staining, the size of eg...

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